Subject Requirements

Key Population Characteristics

• Adults aged 40–80 years
• Clinical diagnosis of knee or hip osteoarthritis
• Symptoms present for at least 6 months
• Radiographic evidence consistent with osteoarthritis
• Moderate to severe pain involving the designated index joint
• Functional limitation associated with the index joint
• Able to understand and complete electronic patient-reported outcome assessments
• Able to participate in voice-enabled assessments
• Willing to comply with study visits and protocol requirements

Inclusion Criteria

Participants must:

• Be 40–80 years of age
• Provide informed consent
• Have a clinical diagnosis of osteoarthritis of the knee or hip
• Have symptoms involving the index joint for at least 6 months
• Have radiographic evidence consistent with osteoarthritis
• Have moderate to severe index-joint pain at screening and baseline
• Demonstrate functional limitation associated with the index joint
• Be able to complete electronic assessments in the study language
• Be capable of participating in conversational voice assessments
• Be willing to comply with study procedures
• Maintain protocol-permitted background therapies as required

Exclusion Criteria

Participants will be excluded for:

• Inflammatory arthritis, including rheumatoid arthritis
• Significant joint disease other than osteoarthritis affecting interpretation of study outcomes
• Recent major surgery involving the index joint
• Planned knee or hip replacement during the study
• Recent intra-articular therapy within the protocol-defined washout period
• Serious uncontrolled medical illness
• Active infection affecting study participation
• Current participation in another interventional clinical trial
• Any condition that, in the investigator's judgment, could interfere with reliable assessment or participant safety